MARINE: Multi-Center, PlAcebo-Controlled, Randomized, Double-BlINd, 12-week study with an open-label Extension (NCT01047683)

In patients with hypertriglyceridaemia, icosapent ethyl (IPE) 4 g/day and 2 g/day significantly reduced placebo-corrected triglyceride (TG) levels by 33.1% (p<0.0001) and 19.7% (p=0.0051) respectively, and improved other lipid parameters, without significantly increasing LDL cholesterol.